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As shown in Scheme 6, Heck-type cross-couplings can be performed by suspending a halogenated tetracycline compound ( e.g., 7-iodosancycline, 6A) and an appropriate palladium or other transition metal catalyst ( e.g., Pd(OAc) 2 and CuI) in an appropriate solvent ( e.g., degassed acetonitrile). Took it on and off for years and it worked ok for me.
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